Ultrashort Cationic Lipopeptides and Lipopeptoids Selectively Induce Cytokine Production in Macrophages

Guanidylation and Tail Effects in Cationic Antimicrobial Lipopeptoids

BACKGROUND Cationic antimicrobial peptides (CAMPs) are attractive scaffolds for the next generation of antimicrobial compounds, due to their broad spectrum of activity against multi-drug resistant bacteria and the reduced fitness of CAMP-insensitive mutants. Unfortunately, they are limited by poor in vivo performance, including ready cleavage by endogenous serum proteases. METHODOLOGY/PRINCIP...

Ultrashort Cationic Lipopeptides Pathogens In Vitro and In Planta with Inhibition of Fungal and Bacterial Plant

Inhibition of fungal and bacterial plant pathogens in vitro and in planta with ultrashort cationic lipopeptides.

Plant diseases constitute an emerging threat to global food security. Many of the currently available antimicrobial agents for agriculture are highly toxic and nonbiodegradable and cause extended environmental pollution. Moreover, an increasing number of phytopathogens develop resistance to them. Recently, we have reported on a new family of ultrashort antimicrobial lipopeptides which are compo...

An alpha-helical cationic antimicrobial peptide selectively modulates macrophage responses to lipopolysaccharide and directly alters macrophage gene expression.

Certain cationic antimicrobial peptides block the binding of LPS to LPS-binding protein and reduce the ability of LPS to induce the production of inflammatory mediators by macrophages. To gain a more complete understanding of how LPS activates macrophages and how cationic peptides influence this process, we have used gene array technology to profile gene expression patterns in macrophages treat...

بررسی فعالیت ماکروفاژهای صفاقی موش C57BL/6 پس از فاگوسیتوز سلول‌های بنیادی مزانشیمی ژله وارتون آپوپتوز شده

Background: Macrophages are one of the most important immune cells. Macrophages can be divided into two main subgroups of classical or inflammatory macrophages(M1) and alternative or non -inflammatory macrophages or (M2), due to different stimuli. One of the factors that causes the macrophage to orient towards M2, is the phagocytosis of apoptosis cells (efferocytosis). The phagocytosis of mesen...